Miyamoto K
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Jpn J Psychiatry Neurol. 1990 Sep;44(3):629-36. doi: 10.1111/j.1440-1819.1990.tb01639.x.
The separate effects of pimozide, haloperidol and chlorpromazine on conditioned behavioral responses and whether there is a difference when the drug is administered accompanied by a sound stimulus were examined in rats. The results showed a similar degree of inhibition could be obtained by saline plus sound as that by pimozide alone. The pimozide with sound group showed a higher inhibition rate than that of the other two groups of rats. In the haloperidol with sound group, a stronger inhibition appeared and furthermore when the injection was discontinued, conditioned abnormal behavior that had been inhibited began to recover. The chlorpromazine group was similar to the haloperidol group. This means that repeated saline injections accompanied by sound and each drug individually inhibits conditioned abnormal behavior and that each drug combined with sound causes the strongest inhibition. The findings obtained suggested that the antipsychotics examined could have conditioned drug effects.
研究了匹莫齐特、氟哌啶醇和氯丙嗪对大鼠条件性行为反应的单独作用，以及药物与声音刺激同时给药时是否存在差异。结果表明，生理盐水加声音刺激所产生的抑制程度与单独使用匹莫齐特相似。匹莫齐特与声音刺激组的抑制率高于其他两组大鼠。在氟哌啶醇与声音刺激组中，出现了更强的抑制作用，而且当注射停止时，被抑制的条件性异常行为开始恢复。氯丙嗪组与氟哌啶醇组相似。这意味着，伴随声音刺激的重复生理盐水注射以及每种药物单独使用时，均可抑制条件性异常行为，且每种药物与声音刺激联合使用时产生的抑制作用最强。所得研究结果表明，所检测的抗精神病药物可能具有条件性药物效应。
