Paciaroni E, Antonicelli R, Lipponi G, Amadio L
Centro di Patologia Cardiovascolare, Istituto INRCA (Italian National Research Centre of Aging), Ancona.
Minerva Cardioangiol. 1990 Oct;38(10):415-21.
This paper deals with the problems of hypercholesterolaemia in the elderly. We have significant results that show an important relationship between serum cholesterol and cardiovascular diseases in the adult, but the same has not yet been definitely established for the elderly. After examination of the available data, the Authors suggest that--after a through clinical evaluation--the elderly should also be treated given that there are data to suggest and hypothesize the positive action of a hypolipemic diet until at least the age of seventy five years. The therapy, whenever possible, could be dietetic; but from relevant results obtained, used together with HMG-CoA reductase inhibitors, these drugs are a good therapeutic approach to the problem, also in the elderly. To support this opinion, the Authors show the results obtained with the use of Simvastatin in a group of old patients.
本文探讨老年人高胆固醇血症问题。我们有显著结果表明成人血清胆固醇与心血管疾病之间存在重要关联,但老年人的情况尚未明确证实。在审查现有数据后,作者建议——经过全面临床评估——鉴于有数据表明并假设低脂饮食至少在七十五岁之前有积极作用,老年人也应接受治疗。只要有可能,治疗方法可以是饮食疗法;但从获得的相关结果来看,与HMG - CoA还原酶抑制剂联合使用,这些药物也是解决该问题的良好治疗方法,对老年人同样适用。为支持这一观点,作者展示了在一组老年患者中使用辛伐他汀所获得的结果。