Mizoguchi Y, Ichikawa Y, Kioka K, Kobayashi K, Yamamoto S, Morisawa S
Third Department of Internal Medicine, Osaka City University Medical School.
Osaka City Med J. 1990 Nov;36(2):121-8.
In order to examine whether the platelet-activating factor (PAF) plays a role in the induction of liver cell injury, the effects of a PAF antagonist were studied in an experimental model of mice with acute liver cell injury induced by intravenous injection of heat-killed Propionibacterium acnes (P. acnes) and lipopolysaccharide. As a result, an intravenous injection of the PAF antagonist was shown to improve the histological changes in the liver, reducing the degree of focal tissue necrosis. In addition, liver adherent cells isolated from normal mice and from those pretreated with P. acnes were shown to produce PAF by stimulation with calcium ionophore A 23187. These results suggested that PAF produced by liver adherent cells may be involved in the induction of liver cell injury.
为了研究血小板活化因子（PAF）是否在肝细胞损伤的诱导中起作用，在通过静脉注射热灭活痤疮丙酸杆菌（P. acnes）和脂多糖诱导急性肝细胞损伤的小鼠实验模型中研究了PAF拮抗剂的作用。结果显示，静脉注射PAF拮抗剂可改善肝脏的组织学变化，减轻局灶性组织坏死程度。此外，从正常小鼠和用P. acnes预处理的小鼠中分离的肝贴壁细胞经钙离子载体A 23187刺激后显示可产生PAF。这些结果表明，肝贴壁细胞产生的PAF可能参与肝细胞损伤的诱导。
