Wilson T
Department of Cellular and Molecular Biology, University of Auckland, New Zealand.
Reprod Fertil Dev. 1990;2(5):511-21. doi: 10.1071/rd9900511.
Phospholipase A2 plays a major role in controlling PG synthesis. Regulation of the activity of this enzyme probably holds the key to the onset of labour. Both PLA2 and PLC can contribute to arachidonate release and PG production in cells, but PLA2 appears to be the main role of synthesis. Phospholipase A2 and PLC can be activated independently of each other; an influx of external calcium is required for PLA2 activation. It is suggested that PLC contributes to PG synthesis through product stimulation of protein kinase C which maintains a pool of free arachidonate by inhibiting reincorporation into the cell membrane. The regulatory role for lipocortin in phospholipase inhibition is controversial and unlikely to be relevant to the onset of labour.
磷脂酶A2在控制前列腺素合成中起主要作用。该酶活性的调节可能是分娩发动的关键。磷脂酶A2和磷脂酶C都可促使细胞内花生四烯酸释放和前列腺素生成，但磷脂酶A2似乎是合成的主要角色。磷脂酶A2和磷脂酶C可相互独立激活；磷脂酶A2的激活需要细胞外钙内流。有人提出，磷脂酶C通过产物刺激蛋白激酶C来促进前列腺素合成，蛋白激酶C通过抑制花生四烯酸重新掺入细胞膜来维持游离花生四烯酸池。脂皮质素在抑制磷脂酶方面的调节作用存在争议，不太可能与分娩发动相关。
