Turgman J, Braham J, Modan B, Goldhammer Y
Eur Neurol. 1978;17(3):149-54. doi: 10.1159/000114938.
Of 150 new cases of nasopharyngeal carcinoma diagnosed in Israel during a 9-year period (nationwide study 1960--1968), 74 patients developed neurological complications. In 92% of the cases, neurologic deficits were confined exclusively to cranial nerves. The majority of these patients presented general symptoms of disease such as neck masses, head and facial pain, or nasal and aural disorders. In 23 patients (34%), the initial presentation was of neurologic disability. The most frequently affected nerves were the abducens and the trigeminal. In the fully developed clinical picture, ocular and trigeminal lesions predominated. 5-year survival in patients with cranial nerve involvement was 21% as compared to 55% in those without such lesions. Survival was not influenced by delayed diagnosis.
在以色列9年期间（1960 - 1968年全国性研究）确诊的150例鼻咽癌新病例中，74例患者出现了神经并发症。在92%的病例中，神经功能缺损仅局限于颅神经。这些患者大多数表现出疾病的一般症状，如颈部肿块、头面部疼痛或鼻耳疾病。23例患者（34%）最初表现为神经功能障碍。最常受累的神经是外展神经和三叉神经。在完全发展的临床症状中，眼部和三叉神经病变占主导。颅神经受累患者的5年生存率为21%，而无此类病变的患者为55%。生存情况不受诊断延迟的影响。
