[二硫代氨基甲酸盐类农药作用下大鼠肝脏溶酶体装置的构效关系]

[Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides].

作者信息

Shubitidze T M, Busova T N, Riazanova R A, Tabagari S I

出版信息

Vopr Med Khim. 1990 Nov-Dec;36(6):24-6.

PMID:2075716

Abstract

Total and non-sedimentable activity of cathepsins A, B, C and D in rat liver tissue as well as activity of these lysosomal proteinases in blood serum were studied during intragastric administration of tetramethyl thiuramdisulfide (TMTD), polymartsine and tsineb within 30 days at a dose of 1/20 LD50. The enzymatic activity alterations, which involved a decrease in total activity of lysosomal proteinases and an increase of the activity in non-sedimentable fraction and blood serum, were distinctly decreased in series: TMTD--polymartsine--tsineb. The data obtained suggest that structure-functional state of lysosomes was considerably altered in response to the effect of dithiocarbamate-containing pesticides.

摘要

在大鼠肝组织中，对组织蛋白酶A、B、C和D的总活性及非沉淀活性，以及在血清中这些溶酶体蛋白酶的活性进行了研究。在30天内，以1/20 LD50的剂量经胃内给予大鼠四甲基秋兰姆二硫化物（TMTD）、多果定和福美锌。酶活性的改变包括溶酶体蛋白酶总活性降低以及非沉淀部分和血清中活性增加，这种改变在TMTD - 多果定 - 福美锌这一系列中明显减弱。所得数据表明，含二硫代氨基甲酸盐的农药作用导致溶酶体的结构 - 功能状态发生显著改变。