Dzodzuashvili V U
Vopr Med Khim. 1988 Mar-Apr;34(2):46-9.
Total and non-sedimentable activities of lysosomal proteinases were studied in rat gastric mucose under conditions of normal state and of ulcer development as well as after treatment of the ulcer area with contrical and with the mixture containing contrical and medical glue MK-8. Both total activity of cathepsins A, B, C and D and their non-sedimentable activity were increased by 32-102% and 44-94%, respectively, under conditions of ulcerogenesis. Contrical and the mixture of the drug with glue MK-8 normalized the enzymatic activity studied; the mixture containing the inhibitor was the most effective. Inhibitors of proteinases combined with medical plastificators might be used in local treatment of stomach ulcerous disease.
在正常状态、溃疡发展状态以及用抑肽酶和含抑肽酶与医用胶水MK - 8的混合物处理溃疡区域后，研究了大鼠胃黏膜中溶酶体蛋白酶的总活性和非沉积活性。在溃疡形成的情况下，组织蛋白酶A、B、C和D的总活性及其非沉积活性分别增加了32% - 102%和44% - 94%。抑肽酶以及该药物与胶水MK - 8的混合物使所研究的酶活性恢复正常；含抑制剂的混合物最为有效。蛋白酶抑制剂与医用增塑剂联合使用可用于胃溃疡疾病的局部治疗。
