Tsimoyiannis E C, Lekkas E T, Paizis J B, Boulis S A, Page P, Kotoulas O B
Department of Surgery, G. Hatzikosta General Hospital, Ioannina, Greece.
Acta Chir Scand. 1990 Nov-Dec;156(11-12):771-4.
The effect of trimetazidine (an antianginal drug that acts as a scavenger of oxygen radicals) in the prevention of peritoneal adhesions induced by complete vascular obstruction of an ileal segment for 30 minutes followed by reperfusion was investigated in rats. Group A (n = 20) acted as controls. Group B (n = 20) received trimetazidine intravenously in a dose of 2.5 mg/kg 30 minutes before the induction of ischaemia. Group C (n = 20) received the same dose of trimetazidine for 5 days before the experiment, twice a day intraperitoneally, and also intravenously 30 minutes before the induction of ischaemia. Group D (n = 20) received the same dose of trimetazidine intravenously immediately after reperfusion had started. Ten days later adhesions had developed in 90% of the animals of group A, 40% of those in group B (p less than 0.001), 5% of those in group C (p less than 0.001), and 60% of those in group D (p less than 0.05). The severity of adhesions was significantly less in the treated groups than in the control animals. Release of creatine phosphokinase during ischaemia and reperfusion significantly increase in groups A, B, and D. These results suggest that trimetazidine reduces the incidence and severity of peritoneal adhesion formation induced by ileal ischaemia and reperfusion, treatment before induction of ischaemia gave better results than treatment given afterwards.
研究了曲美他嗪（一种作为氧自由基清除剂的抗心绞痛药物）对大鼠回肠段完全血管阻塞30分钟后再灌注诱导的腹膜粘连的预防作用。A组（n = 20）作为对照组。B组（n = 20）在缺血诱导前30分钟静脉注射2.5mg/kg剂量的曲美他嗪。C组（n = 20）在实验前5天每天两次腹腔内给予相同剂量的曲美他嗪，并在缺血诱导前30分钟静脉注射。D组（n = 20）在再灌注开始后立即静脉注射相同剂量的曲美他嗪。十天后，A组90%的动物出现粘连，B组40%（p < 0.001），C组5%（p < 0.001），D组60%（p < 0.05）。治疗组的粘连严重程度明显低于对照动物。A组、B组和D组在缺血和再灌注期间肌酸磷酸激酶的释放显著增加。这些结果表明，曲美他嗪可降低回肠缺血再灌注诱导的腹膜粘连形成的发生率和严重程度，缺血诱导前治疗比之后治疗效果更好。
