Damas J, Remacle-Volon G, Nguyen T P
Université de Liège, Belgium.
Arch Int Pharmacodyn Ther. 1990 Jul-Aug;306:161-9.
WEB 2086 reduced the increase in vascular permeability induced by platelet-activating factor (PAF-acether) in rat abdominal skin. Injected alone, WEB 2086 did not modify the oedema induced by zymosan in rat paw. However, administered with methysergide and mepyramine, WEB 2086 reduced the development of this oedema during the first two hours. WEB 2086 also reduced the volume of the exudate induced by zymosan in the peritoneal cavity and its content in leucocytes. Methysergide and mepyramine reduced the volume of the peritoneal exudate. BW755C inhibited the peritoneal accumulation of fluid and of leucocytes. Indomethacin was inactive. The inhibitory effect of WEB 2086 suggests that PAF-acether is involved in the inflammatory responses induced by zymosan in rats beside other endogenous factors such as lipoxygenase products and mast cell amines.
WEB 2086可减轻血小板活化因子（PAF-乙醚）诱导的大鼠腹部皮肤血管通透性增加。单独注射时，WEB 2086不会改变酵母聚糖诱导的大鼠爪部水肿。然而，与麦角新碱和甲氧苄胺嘧啶合用时，WEB 2086在前两小时可减轻该水肿的发展。WEB 2086还可减少酵母聚糖诱导的腹腔渗出液体积及其白细胞含量。麦角新碱和甲氧苄胺嘧啶可减少腹腔渗出液体积。BW755C可抑制腹腔内液体和白细胞的积聚。吲哚美辛无活性。WEB 2086的抑制作用表明，除了其他内源性因素如脂氧合酶产物和肥大细胞胺类外，PAF-乙醚也参与了酵母聚糖诱导的大鼠炎症反应。
