Sorimachi K, Craik D J, Lloyd E J, Beyreuther K, Masters C L
School of Pharmaceutical Chemistry, Victorian College of Pharmacy Ltd., Parkville, Victoria, Australia.
Biochem Int. 1990 Nov;22(3):447-54.
In an attempt to understand the three-dimensional structure of the Alzheimer amyloid protein, a fragment decapeptide was studied by nuclear magnetic resonance spectroscopy. Using two-dimensional techniques, protons close in space were identified and their interproton distances determined. These distances were then used as input data for distance geometry calculations. The resulting three-dimensional structures suggest the presence of a beta-turn in the C-terminus of the decapeptide.
为了了解阿尔茨海默病淀粉样蛋白的三维结构，通过核磁共振光谱对一个十肽片段进行了研究。使用二维技术，确定了空间上接近的质子，并测定了它们之间的质子间距离。然后将这些距离用作距离几何计算的输入数据。所得的三维结构表明该十肽的C末端存在一个β-转角。
