劳力性心绞痛时冠状动脉张力增加：钙拮抗剂的有益作用。
Increased coronary tone in exertional angina: the beneficial effects of calcium antagonists.
作者信息
Specchia G, Ardissino D, Ghio S, Barberis P, Colombo M L, De Servi S
机构信息
Divisione di Cardiologia, Policlinico San Matteo, IRCCS, Pavia, Italy.
出版信息
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 5:893-7. doi: 10.1007/BF02018288.
Coronary vasoconstriction may play a relevant role in the pathogenesis of exercise-induced myocardial ischemia, not only in patients with Prinzmetal's angina, but also in patients with chronic stable angina. In these patients the use of calcium antagonists, namely, dihydropyridine derivatives, may be beneficial. Hyperventilation is a simple and sensitive test to discriminate patients with effort angina who will improve their exercise capacity after administration of these drugs.
冠状动脉收缩可能在运动诱发的心肌缺血发病机制中起重要作用，不仅在变异型心绞痛患者中如此，在慢性稳定性心绞痛患者中也是如此。在这些患者中，使用钙拮抗剂，即二氢吡啶衍生物，可能有益。过度通气是一种简单而敏感的试验，可用于鉴别那些在服用这些药物后运动能力将得到改善的劳力性心绞痛患者。
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