Scognamiglio R, Fasoli G
Department of Cardiology, Medical School, University of Padua, Italy.
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 5:923-8. doi: 10.1007/BF02018294.
In order to assess the effects of nifedipine on left ventricular diastolic abnormalities, 26 patients (mean age 52 year, range 42-66) were studied 10 days after a first myocardial infarction, at rest and during handgrip by Doppler examination. The time-velocity integral for the rapid (E) and atrial (A) filling phases and the E/A ration were used; stroke volume was calculated as the aortic time-velocity integral times the cross-sectional valvular area. Twenty age-matched normal subjects constituted the controls. Twenty-one patients had a reversal of the early to late diastolic filling pattern; five patients had a restrictive pattern. Nifedipine normalized left ventricular filling in patients with a reverse pattern, both at rest and during handgrip. Moreover, these patients showed a descending left ventricular function curve by relating at rest and handgrip values of cardiac index and the E/A ratio. After nifedipine, these study patients showed an ascending left ventricular curve, similar to that of normal subjects, with an increase in cardiac index and a slight decrease in the E/R ratio. No beneficial effects were detectable in patients with a restrictive pattern of left ventricular filling.
为了评估硝苯地平对左心室舒张功能异常的影响，对26例首次心肌梗死后10天的患者（平均年龄52岁，范围42 - 66岁）进行了研究，分别在静息状态和握力运动时进行多普勒检查。采用快速充盈期（E）和心房充盈期（A）的时间 - 速度积分以及E/A比值；每搏量通过主动脉时间 - 速度积分乘以瓣膜横截面积来计算。20名年龄匹配的正常受试者作为对照。21例患者舒张早期至晚期的充盈模式发生逆转；5例患者为限制性模式。硝苯地平使静息状态和握力运动时充盈模式逆转的患者左心室充盈恢复正常。此外，通过关联静息和握力运动时心脏指数及E/A比值的值，这些患者显示出左心室功能曲线下降。服用硝苯地平后，这些研究患者显示出上升的左心室曲线，类似于正常受试者，心脏指数增加，E/A比值略有下降。在左心室充盈为限制性模式的患者中未检测到有益作用。
