Ruilope L M, Alcazar J M
Department of Nephrology, 12 de Octubre Hospital, Madrid, Spain.
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 5:979-82. doi: 10.1007/BF02018304.
Calcium entry blockers exert several characteristic effects on renal function that contribute to their blood-pressure lowering capacity. They are able to dilate renal vasculature and, in certain circumstances, can increase the glomerular filtration rate, both effects being dependent on the preexisting vascular tone. Calcium blockers are also able to increase renal sodium excretion, mainly through a direct tubular effect that remains during the chronic administration of these drugs. These effects clearly differentiate calcium entry blockers from nonspecific vasodilators and contribute to their effectiveness when they are used as first-step drugs in the therapy of arterial hypertension.
钙通道阻滞剂对肾功能产生多种独特作用，这些作用有助于其降低血压的能力。它们能够扩张肾血管，在某些情况下还可增加肾小球滤过率，这两种作用均取决于血管的原有张力。钙通道阻滞剂还能够增加肾钠排泄，主要是通过直接的肾小管效应，且在长期服用这些药物期间这种效应持续存在。这些作用明显将钙通道阻滞剂与非特异性血管扩张剂区分开来，并在它们作为治疗动脉高血压的一线药物使用时，有助于其发挥疗效。
