Saito Y, Shirai K, Uchino J, Okazawa M, Hattori Y, Yoshida T, Yoshida S
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 5:987-90. doi: 10.1007/BF02018306.
Pulse wave velocity (PWV) is known to reflect the stiffness of the aorta, one of the major features of atherosclerosis. To clarify the severity and progression mechanism of atherosclerosis in hemodialysis patients and the preventive effect of nifedipine, PWV was annually measured for 2 years, and the change of PWV and contributory factors were analyzed. PWV in hemodialysis patients was faster than in age-matched normal controls. PWV was correlated with the duration of hemodialysis. delta PWV, which is obtained from the difference in PWV over 1 year, was positively correlated with age, high blood pressure, and serum cholesterol levels and was negatively correlated with HDL levels. The Ca x Pi value was also positively correlated with delta PWV. Nifedipine was administered to 47 patients for 2 years, and the change of PWV was compared with age-matched control hemodialysis patients. The PWV of the control group was gradually increased by 10%. The PWV of the group given nifedipine decreased by 2%. These results suggested that administration of nifedipine may prevent the progression of PWV in hemodialysis patients and may decrease the progression of atherosclerosis.
脉搏波速度（PWV）已知可反映主动脉僵硬度，这是动脉粥样硬化的主要特征之一。为阐明血液透析患者动脉粥样硬化的严重程度和进展机制以及硝苯地平的预防作用，连续两年每年测量PWV，并分析PWV的变化及相关因素。血液透析患者的PWV比年龄匹配的正常对照者更快。PWV与血液透析时间相关。通过1年内PWV差值获得的ΔPWV与年龄、高血压和血清胆固醇水平呈正相关，与高密度脂蛋白（HDL）水平呈负相关。钙磷乘积（Ca×Pi）值也与ΔPWV呈正相关。对47例患者给予硝苯地平治疗2年，并将其PWV变化与年龄匹配的对照血液透析患者进行比较。对照组的PWV逐渐升高了10%。给予硝苯地平组的PWV下降了2%。这些结果表明，给予硝苯地平可能预防血液透析患者PWV的进展，并可能减缓动脉粥样硬化的进展。
