Makino K, Ohshima H, Kondo T
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Biophys Chem. 1990 Nov;38(3):231-9. doi: 10.1016/0301-4622(90)87005-6.
A lag time during the period of variation in solute concentration in the receiver phase and overshoot in that in the membrane phase have been predicted to occur with a kinetic model for membrane transport which takes into account both the membrane volume and the partitioning kinetics (Makino et al., Biophys. Chem. 35 (1990) 85). The duration of the lag time becomes longest when the donor and receiver phases have the same volume. This maximum grows in length with increase in the partition coefficient, tending to be proportional to the volume fraction of the receiver phase. Moreover, it displays an increase in length with decreasing membrane volume fraction. Overshoot occurs only when the volume fraction of the receiver phase is greater than that of the donor. Overshoot is observed during the earlier stages of membrane transport when the partition coefficient is smaller or the volume fraction of the receiver phase is larger.
利用一个考虑了膜体积和分配动力学的膜运输动力学模型预测，在接受相溶质浓度变化期间会出现滞后时间，而在膜相中会出现超调现象（牧野等人，《生物物理化学》35卷（1990年）第85页）。当供体相和接受相体积相同时，滞后时间的持续时间最长。这个最长值会随着分配系数的增加而变长，趋于与接受相的体积分数成正比。此外，它还会随着膜体积分数的减小而变长。只有当接受相的体积分数大于供体相时才会出现超调现象。当分配系数较小或接受相的体积分数较大时，在膜运输的早期阶段会观察到超调现象。
