Dohi M, Kaiho F, Suzuki A, Sekiguchi N, Nakajima N, Nomura H, Kato Y
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2877-9. doi: 10.1248/cpb.38.2877.
The enhancing effects of myristyl lactate (ML) and lauryl lactate (LL) on the percutaneous absorption of indomethacin (ID) from test solutions in propylene glycol (PG) were investigated in rats. ID absorption was observed to be markedly enhanced by the addition of ML or LL to PG as compared with the control (PG alone). The marked enhancing effects were observed at concentrations greater than 3% ML and 3% LL in PG. In particular, the maximal enhancement of percutaneous absorption of ID was achieved at 5% ML and LL. To elucidate the mode of action of ML as an enhancer, the percutaneous absorption of ID through the skin pretreated with ML alone was investigated. It was suggested that ML acts on the stratum corneum to produce its effect.
在大鼠中研究了肉豆蔻醇乳酸酯（ML）和月桂醇乳酸酯（LL）对吲哚美辛（ID）从丙二醇（PG）测试溶液中经皮吸收的增强作用。与对照组（仅PG）相比，观察到向PG中添加ML或LL可显著增强ID的吸收。在PG中ML和LL浓度大于3%时观察到显著的增强作用。特别是，在5%的ML和LL时实现了ID经皮吸收的最大增强。为阐明ML作为增强剂的作用方式，研究了ID单独通过用ML预处理的皮肤的经皮吸收。提示ML作用于角质层以产生其效果。
