Ośmiałowska Z, Nartowicz-Słoniewska M, Słomiński J M, Krupa-Wojciechowska B
Department of Diagnostic Laboratory, Medical Academy, Gdańsk, Poland.
Eur J Clin Pharmacol. 1990;39(4):403-4. doi: 10.1007/BF00315419.
The effect of 6 weeks of nifedipine 30-60 mg/d on platelet aggregation and lipid parameters has been studied. A diminution in ADP-, adrenaline- and collagen-induced aggregation was observed. In the case of adrenaline- and collagen-stimulated aggregation the decrease was statistically significant. It was found that platelets which aggregated markedly during the placebo treatment were most strongly inhibited by nifedipine. The changes in lipid parameters were not significantly correlated with changes in aggregation.
研究了硝苯地平30 - 60毫克/天服用6周对血小板聚集和血脂参数的影响。观察到二磷酸腺苷（ADP）、肾上腺素和胶原诱导的聚集减少。在肾上腺素和胶原刺激的聚集中，这种减少具有统计学意义。发现安慰剂治疗期间明显聚集的血小板受硝苯地平抑制作用最强。血脂参数的变化与聚集变化无显著相关性。
