Leor R, Feinstein M, Hod H, Rabinowitz B, Kaplinsky E
The Heart Institute, Sheba Medical Center, Tel Hashomer, Israel.
Eur J Clin Pharmacol. 1990;39(5):521-3. doi: 10.1007/BF00280948.
In order to evaluate the surface tension lowering effect of lidocaine 0.4% on a 5% glucose solution, drop size has been measured in intravenous sets of 60 drops per ml. The relationship between the number of drops per ml and the pH of the solution was sigmoidal, from 63 drops/ml at pH5 to 95 drops/ml at pH 10. Without lidocaine, the effect of pH on the drop count of the 5% glucose solution was negligible. The surface tension lowering effect of lidocaine may account for significant decreases in apparent bioavailability and delivered lidocaine when high pH solutions are used with drop counting infusion pumps.
为了评估0.4%利多卡因对5%葡萄糖溶液的表面张力降低效果，已在每毫升60滴的静脉输液器中测量了液滴大小。每毫升液滴数与溶液pH值之间的关系呈S形，从pH5时的63滴/毫升到pH10时的95滴/毫升。在没有利多卡因的情况下，pH值对5%葡萄糖溶液液滴计数的影响可忽略不计。当高pH值溶液与滴数计数输液泵一起使用时，利多卡因的表面张力降低效果可能是导致表观生物利用度和输送的利多卡因显著降低的原因。
