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1
An RME1-independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation.酿酒酵母中一种不依赖RME1的孢子形成控制途径通过IME1转录物积累发挥作用。
Genetics. 1990 Dec;126(4):823-35. doi: 10.1093/genetics/126.4.823.
2
IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae.IME4，一个在酿酒酵母中介导减数分裂的MAT和营养控制的基因。
Mol Cell Biol. 1992 Mar;12(3):1078-86. doi: 10.1128/mcb.12.3.1078-1086.1992.
3
IME1, a positive regulator gene of meiosis in S. cerevisiae.IME1，酿酒酵母中减数分裂的一个正向调节基因。
Cell. 1988 Mar 25;52(6):853-62. doi: 10.1016/0092-8674(88)90427-8.
4
The sporulation capable (sca) mutation of Saccharomyces cerevisiae is an allele of the SIR2 gene.酿酒酵母的孢子形成能力（sca）突变是SIR2基因的一个等位基因。
Mol Gen Genet. 1988 Mar;211(3):430-4. doi: 10.1007/BF00425696.
5
rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation.酿酒酵母rme1突变：定位及孢子形成中交配型基因座控制的旁路
Mol Cell Biol. 1981 Oct;1(10):958-60. doi: 10.1128/mcb.1.10.958-960.1981.
6
Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA.交配型调控的长链非编码RNA IRT1的转录由雷帕霉素靶蛋白复合体1（TORC1）和蛋白激酶A（PKA）控制。
Curr Genet. 2017 May;63(2):325-329. doi: 10.1007/s00294-016-0639-6. Epub 2016 Aug 12.
7
Genetic regulation of differentiation towards meiosis in the yeast Saccharomyces cerevisiae.酿酒酵母中减数分裂分化的遗传调控。
Genome. 1989;31(1):95-9. doi: 10.1139/g89-018.
8
Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae.IME1表达在酿酒酵母减数分裂调控中的作用。
Mol Cell Biol. 1990 Dec;10(12):6103-13. doi: 10.1128/mcb.10.12.6103-6113.1990.
9
A mutation that permits the expression of normally silent copies of mating-type information in Saccharomyces cerevisiae.一种能使酿酒酵母中通常沉默的交配型信息拷贝得以表达的突变。
Genetics. 1979 Sep;93(1):13-35. doi: 10.1093/genetics/93.1.13.
10
A long region upstream of the IME1 gene regulates meiosis in yeast.IME1基因上游的一个长区域调控酵母中的减数分裂。
Mol Gen Genet. 1989 Aug;218(2):308-14. doi: 10.1007/BF00331283.

引用本文的文献

1
Multiple and distinct activation and repression sequences mediate the regulated transcription of IME1, a transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae.多个不同的激活和抑制序列介导了IME1的调控转录，IME1是酿酒酵母中减数分裂特异性基因的转录激活因子。
Mol Cell Biol. 1998 Apr;18(4):1985-95. doi: 10.1128/MCB.18.4.1985.
2
Participation of the yeast activator Abf1 in meiosis-specific expression of the HOP1 gene.酵母激活因子Abf1参与HOP1基因的减数分裂特异性表达。
Mol Cell Biol. 1996 Jun;16(6):2777-86. doi: 10.1128/MCB.16.6.2777.
3
Post-transcriptional regulation of IME1 determines initiation of meiosis in Saccharomyces cerevisiae.IME1的转录后调控决定了酿酒酵母减数分裂的起始。
Mol Gen Genet. 1993 Mar;237(3):375-84. doi: 10.1007/BF00279441.
4
Control of meiotic gene expression in Saccharomyces cerevisiae.酿酒酵母减数分裂基因表达的调控
Microbiol Rev. 1994 Mar;58(1):56-70. doi: 10.1128/mr.58.1.56-70.1994.
5
Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1.RIM11的分析，一种磷酸化减数分裂激活因子IME1的酵母蛋白激酶。
Mol Cell Biol. 1994 Dec;14(12):7909-19. doi: 10.1128/mcb.14.12.7909-7919.1994.
6
Requirement for RGR1 and SIN4 in RME1-dependent repression in Saccharomyces cerevisiae.酿酒酵母中RME1依赖性抑制作用对RGR1和SIN4的需求。
Genetics. 1994 Nov;138(3):577-86. doi: 10.1093/genetics/138.3.577.
7
IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae.IME4，一个在酿酒酵母中介导减数分裂的MAT和营养控制的基因。
Mol Cell Biol. 1992 Mar;12(3):1078-86. doi: 10.1128/mcb.12.3.1078-1086.1992.

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Mutants Showing Heterothallism from a Homothallic Strain of SACCHAROMYCES CEREVISIAE.酵母属中从同宗配合品系突显出异宗配合的突变体。
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Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.对因一种因子和α因子信息素而对G1期阻滞超敏感的酿酒酵母突变体的分离与遗传分析。
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rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation.酿酒酵母rme1突变：定位及孢子形成中交配型基因座控制的旁路
Mol Cell Biol. 1981 Oct;1(10):958-60. doi: 10.1128/mcb.1.10.958-960.1981.
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Meiosis in haploid yeast.单倍体酵母中的减数分裂。
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The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae.酿酒酵母交配型基因座的编码DNA序列。
Cell. 1981 Nov;27(1 Pt 2):15-23. doi: 10.1016/0092-8674(81)90356-1.
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Control of cell type in yeast by the mating type locus. The alpha 1-alpha 2 hypothesis.酵母中交配型基因座对细胞类型的控制。α1-α2假说。
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Transformation of intact yeast cells treated with alkali cations.经碱金属阳离子处理的完整酵母细胞的转化
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Beta-galactosidase gene fusions for analyzing gene expression in escherichia coli and yeast.用于分析大肠杆菌和酵母中基因表达的β-半乳糖苷酶基因融合体
Methods Enzymol. 1983;100:293-308. doi: 10.1016/0076-6879(83)00063-4.
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Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast.构建并使用在酵母中表达的与lacZ（β-半乳糖苷酶）的基因融合体。
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Isolation of genes expressed preferentially during sporulation in the yeast Saccharomyces cerevisiae.酿酒酵母中孢子形成过程中优先表达基因的分离。
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酿酒酵母中一种不依赖RME1的孢子形成控制途径通过IME1转录物积累发挥作用。

An RME1-independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation.

作者信息

Kao G, Shah J C, Clancy M J

机构信息

Department of Biological Sciences, University of New Orleans, Louisiana 70148.

出版信息

Genetics. 1990 Dec;126(4):823-35. doi: 10.1093/genetics/126.4.823.

DOI:10.1093/genetics/126.4.823
PMID:2076816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1204281/
Abstract

The RES1-1 mutation was isolated on the basis of its ability to allow MATa/MAT alpha diploid Saccharomyces cerevisiae cells to express a late sporulation-regulated gene, SPR3, in the presence of excess copies of RME1. RME1 is a repressor of meiosis that is normally expressed in cells that lack the a1/alpha 2 repressor encoded by MAT. The RES1-1 mutation also supports sporulation in mat-insufficient diploids. This phenotype does not result from a failure to express RME1 and is not due to activation of the silent copies of mating type information. RES1-1 activates sporulation by allowing IME1 accumulation in all cell types, irrespective of the presence of the MAT products. IME1 is still responsive to RME1 in RES1-1 cells, since double mutants (rme1 RES1-1) that are deficient at MAT can sporulate better than either single mutant. RES1-1 is not an allele of IME1.

摘要

RES1-1突变是根据其使MATa/MATα二倍体酿酒酵母细胞在存在过量RME1拷贝的情况下表达晚期孢子形成调控基因SPR3的能力而分离出来的。RME1是减数分裂的一种阻遏物，通常在缺乏由MAT编码的a1/α2阻遏物的细胞中表达。RES1-1突变也支持mat缺陷二倍体的孢子形成。这种表型不是由于未能表达RME1，也不是由于交配型信息沉默拷贝的激活。RES1-1通过允许IME1在所有细胞类型中积累来激活孢子形成，而不管MAT产物的存在与否。在RES1-1细胞中，IME1仍然对RME1有反应，因为在MAT处存在缺陷的双突变体（rme1 RES1-1）比任何一个单突变体都能更好地形成孢子。RES1-1不是IME1的等位基因。