Nielsen L S, Eiberg H, Fenger K, Mohr J
Institute of Medical Genetics, University of Copenhagen, Denmark.
Tissue Antigens. 1990 Oct;36(4):141-8. doi: 10.1111/j.1399-0039.1990.tb01820.x.
Extended MHC haplotypes comprising HLA-A, -B, -DR, C2, BF and GLO1 loci observed in the parents of 497 Danish normal families are presented, with particular regard to the haplotypes that include BF variants or the C22 allele. The known association of HLA-B35, -DR1 with both -A3 and -A11 appeared to depend upon the BF type: HLA-B35, BFS, -DR1 is strongly associated with -A11, whereas -B35,BF*F,-DR1 is strongly associated with -A3. Further, in the present material DZ twins of the same sex shared HLA-haplotypes more often than did twin pairs of different sex.
呈现了在497个丹麦正常家庭的父母中观察到的包含HLA - A、- B、- DR、C2、BF和GLO1基因座的扩展MHC单倍型，特别关注包括BF变体或C22等位基因的单倍型。已知的HLA - B35、- DR1与 - A3和 - A11的关联似乎取决于BF类型：HLA - B35、BFS、- DR1与 - A11强烈相关，而 - B35、BF*F、- DR1与 - A3强烈相关。此外，在本研究材料中，同性别的DZ双胞胎比不同性别的双胞胎对更常共享HLA单倍型。
