Frick O L
School of Medicine, Department of Pediatrics, San Francisco, CA 94143.
Allerg Immunol (Paris). 1990 Nov;22(9):368-72.
IgE mediated type 1 hypersensitivity induces an immediate phase, during the minutes that follow contact with the allergen and is very often associated with a late phase that occurs during the hours that follow contact. The late phase of asthma induced by an IgE--dependent mechanism is linked with a cellular activation (lymphocytes, eosinophils) and release of different mediators (Paf Acether, LTB4, ECFA, MBP, EcP) from those of the immediate phase. Corticosteroids are well known as inhibitors of the late phase. Like cromoglycate, AZELASTINE inhibits both the immediate and late phases.
IgE介导的1型超敏反应会引发即刻反应阶段，即在接触变应原后的几分钟内出现，并且常常与接触变应原数小时后出现的迟发反应阶段相关联。由IgE依赖性机制诱发的哮喘迟发反应阶段与细胞活化（淋巴细胞、嗜酸性粒细胞）以及不同于即刻反应阶段的多种介质（血小板活化因子、白三烯B4、嗜酸性粒细胞趋化因子A、主要碱性蛋白、嗜酸性粒细胞阳离子蛋白）的释放有关。皮质类固醇是众所周知的迟发反应阶段抑制剂。与色甘酸一样，氮卓斯汀可同时抑制即刻反应阶段和迟发反应阶段。
