Raimondi G, Legramante J, Cassarino S, Marazza D, Iellamo F, Massaro M, Bellegrandi F, D'Arcangelo M, Di Nardo P, Spallone A
Dipartimento di Medicina Interna, II Università degli Studi, Tor Vergata, Roma.
Cardiologia. 1990 Jun;35(6):451-7.
Muscular exercise is accompanied by evident and perfectly matched cardiovascular and respiratory adjustments to avoid changes in arterial blood gases. The mechanisms responsible for this perfect regulation have not yet been defined. Our previous experimental investigations have shown that a consistent rate of cardiorespiratory reflex responses to exercise is caused by chemosensitive muscular receptors activation. The 2 different types of classical muscular exercise (rhythmic and isometric exercise) are joined with the 2 different patterns of cardiorespiratory reflex responses attributed in our opinion to the activation of 2 different kinds of muscle receptors (K and P). It has been observed that the increase in ventilation (VE), elicited by activation of both types of chemoreceptors during muscular experimental exercise is not accompanied by significant variations of partial pressure of CO2 (PaCO2) in the arterial blood (isocapnic hyperpnea). This suggest that muscular chemoreceptor activation during physical exercise determines an adequate cardiopulmonary matching. The main purpose of the present study has been to verify, in anesthetized rabbits, if also the chemical activation of muscular receptors was able to evoke reflexly an adequate degree of cardiopulmonary matching. The ventilation reflex changes and the concomitant variations of PaCO2 induced by injection of bradikinin (BK 250 ng) and hypertonic solutions (NaCl 10% 1 ml) in femoral artery have been evaluated in 10 anesthetized rabbits. The PaCO2 modifications observed during reflex hyperpnea have been compared with those recorded during hyperpnea induced by artificial ventilation.(ABSTRACT TRUNCATED AT 250 WORDS)
肌肉运动伴随着明显且完美匹配的心血管和呼吸调节，以避免动脉血气发生变化。负责这种完美调节的机制尚未明确。我们之前的实验研究表明，对运动的心肺反射反应速率一致是由化学敏感肌肉受体的激活引起的。两种不同类型的经典肌肉运动（节律性运动和等长运动）与两种不同模式的心肺反射反应相关联，我们认为这归因于两种不同类型肌肉受体（K和P）的激活。据观察，在肌肉实验性运动期间，两种类型的化学感受器激活所引发的通气增加（VE）并未伴随着动脉血中二氧化碳分压（PaCO2）的显著变化（等碳酸血症性通气过度）。这表明体育锻炼期间肌肉化学感受器的激活决定了适当的心肺匹配。本研究的主要目的是在麻醉兔中验证，肌肉受体的化学激活是否也能反射性地引发适当程度的心肺匹配。在10只麻醉兔中评估了股动脉注射缓激肽（BK 250 ng）和高渗溶液（10% NaCl 1 ml）所诱导的通气反射变化以及PaCO2的伴随变化。将反射性通气过度期间观察到的PaCO2变化与人工通气诱导的通气过度期间记录的变化进行了比较。（摘要截短于250字）
