Cento D, Castaldo C, Arrigo F, Munaò F
Istituto Pluridisciplinare di Clinica Medica e Terapia Medica Generale e Speciale, Università degli Studi, Messina.
Cardiologia. 1990 Aug;35(8):645-50.
The purpose of this study was to evaluate if the occurrence of acute myocardial infarction (AMI) follows a regular pattern during the day and, if so, to assess any difference according to sex and patients' age. To determine 24-hour trend of AMI onset, clinical recordings of patients admitted to the CCU for AMI over a period of 8 years were reviewed: 427 patients (310 men and 117 women, aged 24-95 years), with a first AMI and in whom the time of onset of cardiac pain due to MI could be accurately established by history, were selected. Analysis of hourly distribution of the event was performed using a mathematical model based on Whittaker's method for periodic phenomena. It showed the occurrence is cyclic with 2 waves with periods of 6 and 12 hours in all age groups in men an women. No statistical differences were found between observed figures of periods and values calculated by Fourier analysis. The overall occurrence of MI showed a regular pattern with 4 peaks at 4.00 am, 10.00 am, 4.00 am and 10.00 pm. This periodic behaviour is nearly the same both in men and in women. The occurrence of MI is maximal in the morning (34.2% in men, and 35.9% in women); the minimum was recorded during the evening in male patients over 70 years and during the night in the other age groups; it was recorded during the afternoon and the night in women.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是评估急性心肌梗死（AMI）的发生在一天中是否遵循规律模式，如果是，则根据性别和患者年龄评估是否存在差异。为了确定AMI发病的24小时趋势，回顾了8年间因AMI入住冠心病监护病房（CCU）患者的临床记录：选择了427例患者（310例男性和117例女性，年龄24 - 95岁），这些患者首次发生AMI，且通过病史能够准确确定因心肌梗死导致的心前区疼痛发作时间。使用基于惠特克周期现象方法的数学模型对该事件的每小时分布进行分析。结果显示，在所有年龄组的男性和女性中，AMI的发生呈周期性，有两个波峰，周期分别为6小时和12小时。观察到的周期数据与通过傅里叶分析计算的值之间未发现统计学差异。心肌梗死的总体发生呈现规律模式，在凌晨4点、上午10点、下午4点和晚上10点出现4个峰值。这种周期性行为在男性和女性中几乎相同。心肌梗死的发生在早晨达到峰值（男性为34.2%，女性为35.9%）；在70岁以上男性患者中，傍晚发生率最低，在其他年龄组中夜间发生率最低；女性在下午和夜间发生率最低。（摘要截选至250字）
