维拉帕米对大鼠缺血性肝损伤的保护作用。

Protective effects of verapamil on ischemia-induced hepatic damage in the rat.

作者信息

Shinohara M, Kayashima K, Konomi K

机构信息

First Department of Surgery, Faculty of Medicine, Kyusyu University, Fukuoka, Japan.

出版信息

Eur Surg Res. 1990;22(5):256-62. doi: 10.1159/000129110.

DOI:10.1159/000129110

PMID:2079087

Abstract

The preventive effects of the calcium channel blocker, verapamil, on ischemic liver damage were studied using a rat total hepatic ischemic model. A marked improvement in the survival was obtained by verapamil administration. Following 90 min of hepatic ischemia, 8 of 9 rats (89%) survived in the verapamil-treated group compared to only a 50% survival rate in the saline-treated control group. Furthermore, 56% of the rats still survived after 120 min of ischemia, while there was no survivor in the control group. The recovery of hepatic ATP level following ischemia was significant in the verapamil-treated group, showing the well-preserved mitochondrial function afforded by verapamil administration.

摘要

使用大鼠全肝缺血模型研究了钙通道阻滞剂维拉帕米对缺血性肝损伤的预防作用。给予维拉帕米可显著提高存活率。肝缺血90分钟后，维拉帕米治疗组9只大鼠中有8只（89%）存活，而生理盐水治疗的对照组存活率仅为50%。此外，缺血120分钟后，56%的大鼠仍存活，而对照组无存活者。维拉帕米治疗组缺血后肝ATP水平的恢复显著，表明给予维拉帕米可很好地保留线粒体功能。