Letko G, Falkenberg B, Boschmann M
Clinic of Surgery, Medical Academy of Magdeburg, FRG.
Exp Pathol. 1990;40(2):105-9. doi: 10.1016/s0232-1513(11)80327-0.
The survival of isolated pancreatic acinar cells and of hepatocytes from rats was compared to mimic cell injury and death during the pathogenesis of acute pancreatitis in the presence of varying concentrations of trypsin, chymotrypsin and of the uncoupler 2.4-dinitrophenol (DNP). While hepatocytes were quickly damaged by trypsin they still excluded trypan blue though an excess amount of DNP was added. Pancreocytes revealed a reversed susceptibility to both noxae. The reduced sensitivity of pancreocytes to extracellular trypsin action could represent a special protectiveness against autodigestion and their increased susceptibility to an alteration of the cellular energy state stresses the importance of this factor to the survival of pancreatic tissue under normal and noxious conditions.
将大鼠分离的胰腺腺泡细胞和肝细胞的存活率进行比较，以模拟急性胰腺炎发病过程中在不同浓度的胰蛋白酶、糜蛋白酶和解偶联剂2,4-二硝基苯酚（DNP）存在下的细胞损伤和死亡情况。虽然肝细胞会被胰蛋白酶迅速损伤，但即便加入过量的DNP，它们仍能排斥台盼蓝。胰腺细胞对这两种有害物质表现出相反的敏感性。胰腺细胞对细胞外胰蛋白酶作用的敏感性降低可能代表了一种针对自身消化的特殊保护机制，而它们对细胞能量状态改变的敏感性增加则强调了这一因素在正常和有害条件下对胰腺组织存活的重要性。
