Cannat A, Seligmann M
Br Med J. 1973 Jan 13;1(5845):71-4. doi: 10.1136/bmj.1.5845.71.
Immunological studies were performed on 24 children suffering from juvenile myelomonocytic leukaemia. Strikingly high serum immunoglobulin levels with a frequent tendency towards homogeneity and light-chain imbalance were present, together with a high incidence of antinuclear antibodies (52%) and antihuman IgG antibodies (43%). Members of the families of 19 of the children were also studied. A few similar abnormalities were found in eight families, mostly clustered in four of them. The significance of the association of these immunological aberrations with juvenile myelomonocytic leukaemia is at present unknown. In view of the interrelation observed in experimental models between immunological abnormalities and oncogenic viruses the possibility of a common aetiological factor such as a viral infection during fetal life is suggested.
对24名患有青少年型粒单核细胞白血病的儿童进行了免疫学研究。发现血清免疫球蛋白水平显著升高，常常有均一性倾向和轻链失衡，同时抗核抗体（52%）和抗人IgG抗体（43%）的发生率很高。还对其中19名儿童的家庭成员进行了研究。在8个家庭中发现了一些类似的异常情况，大多数集中在其中4个家庭。目前尚不清楚这些免疫异常与青少年型粒单核细胞白血病之间关联的意义。鉴于在实验模型中观察到免疫异常与致癌病毒之间的相互关系，提示可能存在一个共同的病因因素，如胎儿期的病毒感染。
