Altamura A C, Mauri M C, Girardi T, Panetta B
Department of Psychiatry, Laboratory of Clinical Neuropsychopharmacology, University of Milan, Italy.
Int J Clin Pharmacol Res. 1990;10(4):223-8.
Twenty elderly chronic schizophrenic inpatients of both sexes, age ranging from 60 to 73 years (mean age 63 +/- 0.81 years), diagnosed according to DSM III-R, were treated with fluphenazine decanoate, 12.5 mg intramuscularly, administered every 21 days for six months. Psychopathological features were assessed by means of the Brief Psychiatric Rating Scale at time 0 and then weekly. At 0, 6, 12, 24, 36, 48, 72h and 7, 14 and 21 days after each administration, extrapyramidal side-effects were evaluated using the Extrapyramidal Side-Effects Scale. Fluphenazine was significantly effective in treating symptoms such as emotional withdrawal, blunted affect, suspiciousness, thought disturbances, but not hallucinations. The most severe extrapyramidal side-effects occurred within the first two days of administration of fluphenazine, with a peak after 36 h, following the first four administrations of the drug, possibly related to early peak plasma concentrations. The severity of these effects was reduced after the fifth injection indicating the occurrence of tolerance mechanisms during long-term fluphenazine administration.
二十名年龄在60至73岁之间（平均年龄63±0.81岁）、根据《精神疾病诊断与统计手册》第三版修订本（DSM III-R）诊断的老年慢性精神分裂症住院患者，接受了癸酸氟奋乃静治疗，肌肉注射12.5毫克，每21天给药一次，持续六个月。在治疗开始时（0周）以及随后每周，通过简明精神病评定量表评估精神病理学特征。在每次给药后的0、6、12、24、36、48、72小时以及7、14和21天，使用锥体外系副反应量表评估锥体外系副作用。氟奋乃静在治疗情感退缩、情感迟钝、猜疑、思维紊乱等症状方面显著有效，但对幻觉无效。最严重的锥体外系副作用发生在氟奋乃静给药的头两天内，在首次四次给药后36小时达到峰值，这可能与早期血浆浓度峰值有关。在第五次注射后，这些副作用的严重程度有所降低，表明在长期使用氟奋乃静期间出现了耐受机制。
