大脑局灶性萎缩在衰老和痴呆症正电子发射断层扫描研究中的作用。

The effect of focal cerebral atrophy in positron emission tomographic studies of aging and dementia.

作者信息

Chawluk J B, Dann R, Alavi A, Hurtig H I, Gur R E, Resnick S, Zimmerman R A, Reivich M

机构信息

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.

出版信息

Int J Rad Appl Instrum B. 1990;17(8):797-804. doi: 10.1016/0883-2897(90)90028-y.

DOI:10.1016/0883-2897(90)90028-y

PMID:2079426

Abstract

We used x-ray computed tomographic (XCT) scans to measure the degree of cerebral atrophy in brain regions defined by a region of interest (ROI) anatomy atlas. The same atlas was employed for quantitation of local cerebral glucose metabolic rates (LCMRglc) by PET. PET data were obtained from 9 young controls, 7 healthy elderly controls, and 10 patients with dementia. Cerebrospinal fluid (CSF) in atrophic brain regions was assumed to be metabolically inert, and LCMRglc measurements were corrected for the degree of atrophy. Significantly greater atrophy was seen for 7 of 8 regions in comparisons between demented patients and age-matched controls. This atrophy was most pronounced in superior parietal (SP) regions. Decreases in parietal LCMRglc in dementia patients and SP LCMRglc in old controls were no longer significant after correction for atrophy. These results emphasize the need to consider focal atrophy effects in regional quantitative analyses of emission tomographic data.

摘要

我们使用X射线计算机断层扫描（XCT）来测量由感兴趣区域（ROI）解剖图谱定义的脑区脑萎缩程度。同一图谱用于通过正电子发射断层扫描（PET）定量局部脑葡萄糖代谢率（LCMRglc）。PET数据来自9名年轻对照者、7名健康老年对照者和10名痴呆患者。萎缩脑区的脑脊液（CSF）被认为代谢不活跃，LCMRglc测量值针对萎缩程度进行了校正。在痴呆患者与年龄匹配的对照者的比较中，8个区域中的7个区域出现了明显更大程度的萎缩。这种萎缩在顶叶上部（SP）区域最为明显。校正萎缩后，痴呆患者顶叶LCMRglc的降低以及老年对照者SP LCMRglc的降低不再显著。这些结果强调在发射断层扫描数据的区域定量分析中需要考虑局灶性萎缩效应。