Priatkin R G, Kuz'menko O M
Zh Mikrobiol Epidemiol Immunobiol. 2010 Jul-Aug(4):118-24.
Modern views on secreted proteins of Staphylococcus aureus are analyzed in the review. Spread of this pathogen is partially explained by wide spectrum of proteins secreted by this microorganism. Four groups of proteins secreted by staphylococci could be assigned. These are peptidoglycanhydrolases, intracellular enzymes (proreases, lipases etc.), membrane toxins (hemolyzins and leukocidins), and superantigens. Role of some proteins, especially belonging to latter groups, for the staphylococcal virulence and pathogenesis of staphylococcal infectious is known at this time. Genome sequencing of several strains of S. aureus also allowed to predict main characteristics of many secreted proteins such as molecular mass and spatial structure. Further studies of these proteins could be useful for development of staphylococcal vaccines and other immunity-modifying drugs.
本综述分析了关于金黄色葡萄球菌分泌蛋白的现代观点。这种病原体的传播部分归因于该微生物分泌的蛋白质种类繁多。葡萄球菌分泌的蛋白质可分为四类。它们是肽聚糖水解酶、细胞内酶（蛋白酶、脂肪酶等）、膜毒素（溶血素和杀白细胞素）以及超抗原。目前已知某些蛋白质，尤其是后几类中的蛋白质，在葡萄球菌的毒力和葡萄球菌感染的发病机制中所起的作用。对几株金黄色葡萄球菌的基因组测序也有助于预测许多分泌蛋白的主要特征，如分子量和空间结构。对这些蛋白质的进一步研究可能有助于开发葡萄球菌疫苗和其他免疫调节药物。
