Speare D J
Dept. of Pathology, Ontario Veterinary College, University of Guelph, Canada.
J Comp Pathol. 1990 Nov;103(4):421-32. doi: 10.1016/s0021-9975(08)80030-8.
Ocular lesions associated with natural and experimental outbreaks of gas bubble disease (GBD) in commercial salmonids were assessed histologically and by scanning electron microscopy. Small gas emboli were first detected in the choroid gland of the posterior uvea. In subacute and chronic cases, bubble size increased markedly and localization in retrobulbar and periocular sites was favoured. During the acute phase of GBD, ocular lesions were limited to anatomical displacement of tissue and local degeneration of compressed tissues around the perimeter of bubbles. Subacute sequelae included the formation of anterior synechia, lens cataract, and suppurative panophthalmitis. During chronic stages, when large retrobulbar bubbles had caused severe exophthalmia, there was stretching of the optic nerve and of retinal blood vessels and severe distortion of the posterior aspects of the globe. The sequential development, pathogenesis and persistence of ocular lesions associated with GBD in fish are discussed.
通过组织学检查和扫描电子显微镜对商业鲑科鱼类自然爆发和实验性爆发气泡病（GBD）相关的眼部病变进行了评估。在后部葡萄膜的脉络膜腺中首次检测到小的气体栓子。在亚急性和慢性病例中，气泡大小显著增加，且更倾向于定位在眼球后和眼周部位。在气泡病的急性期，眼部病变仅限于组织的解剖移位以及气泡周边受压组织的局部变性。亚急性后遗症包括虹膜前粘连、晶状体白内障和化脓性全眼球炎。在慢性阶段，当眼球后大的气泡导致严重眼球突出时，会出现视神经和视网膜血管的拉伸以及眼球后部的严重变形。本文讨论了鱼类气泡病相关眼部病变的连续发展、发病机制和持续存在情况。
