3-苄基-3-氮杂双环[3.1.1]庚烷-6-酮：药物化学有前景的构建模块。
3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.
机构信息
Enamine Ltd., Vul. Oleksandra Matrosova 23, 01103 Kyiv, Ukraine.
出版信息
Org Lett. 2010 Oct 1;12(19):4372-5. doi: 10.1021/ol101866x.
PMID:20795656
Abstract
An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.
摘要
描述了一种高效的两步多步合成以前未知的 3-苄基-3-氮杂双环[3.1.1]庚烷-6-酮的方法。该化合物被证明是进一步选择性衍生环丁烷环的有前途的构建块，提供了新型的构象受限的哌啶衍生物。
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