Nakamura J, Haraguchi Y, Asai K, Sasaki H, Shibasaki J
Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
J Pharmacobiodyn. 1990 Aug;13(8):461-7. doi: 10.1248/bpb1978.13.461.
The effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms was investigated. Latamoxef sodium (LMOX, 25 mg/kg/d, intravenously) and cephalexin (CEX, 16.7 mg/kg/d, orally) were administered for 1 or 3 d. The blood concentration of salicyluric acid and salicylic acid following oral, intracecal and rectal administration of salicyluric acid was determined. By the pretreatment with LMOX for 1 or 3 d, the blood concentration of salicylic acid following oral administration of salicyluric acid was slightly decreased. In rabbits pretreated with CEX for 3 d, the blood concentration of salicylic acid was detected at low concentration. By the pretreatment with LMOX and CEX, however, the decrease in the blood concentration of salicylic acid following rectal administration of salicyluric acid was not observed. Although the examination of population of intestinal microorganisms induced by the pretreatment with antibiotics was not performed, the metabolic activity of intestinal microorganisms may be changed.
研究了抗生素预处理对兔肠道微生物中水杨尿酸水解的影响。静脉注射拉氧头孢钠（LMOX，25mg/kg/d）和口服头孢氨苄（CEX，16.7mg/kg/d），给药1或3天。测定水杨尿酸经口服、盲肠内和直肠给药后血液中水杨尿酸和水杨酸的浓度。用LMOX预处理1或3天，口服水杨尿酸后血液中水杨酸的浓度略有下降。在CEX预处理3天的兔子中，检测到血液中水杨酸的浓度较低。然而，用LMOX和CEX预处理后，未观察到直肠给药水杨尿酸后血液中水杨酸浓度的下降。虽然未对抗生素预处理诱导的肠道微生物群进行检测，但肠道微生物的代谢活性可能发生了变化。
