Liu L Y, Gemba M
Division of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
J Pharmacobiodyn. 1990 Aug;13(8):507-11. doi: 10.1248/bpb1978.13.507.
The effect of treatment of rats with ginsenosides (extracted from Panax ginseng) on transport of p-aminohippurate (PAH) in renal cortical slices was studied for an in vitro reflection of PAH secretion in the proximal tubules in the kidney. The treatment of rats with ginsenosides stimulated PAH accumulation in the slices and tended to prevent the decrease in PAH accumulation in incubated slices from the rats with acute renal failure caused by cisplatin or ischemia followed by reperfusion. Ginsenoside treatment affected other biochemical responses in renal cortical slices, with a decrease in adenosine triphosphate level and an increase in potassium level. The latter may lead to the stimulation of PAH transport in the slices, but additional information on the cellular action of ginsenosides is needed for this conclusion. It may be that the stimulatory effect of ginsenosides on PAH accumulation in the slices counterbalances the decrease in PAH accumulation in the slices from rats with acute renal failure.
为了在体外反映肾脏近端小管中对氨基马尿酸（PAH）的分泌情况，研究了用人参皂苷（从人参中提取）处理大鼠对肾皮质切片中PAH转运的影响。用人参皂苷处理大鼠可刺激切片中PAH的蓄积，并倾向于防止顺铂或缺血再灌注所致急性肾衰竭大鼠的孵育切片中PAH蓄积的减少。人参皂苷处理影响肾皮质切片中的其他生化反应，三磷酸腺苷水平降低，钾水平升高。后者可能导致切片中PAH转运的刺激，但这一结论还需要关于人参皂苷细胞作用的更多信息。可能是人参皂苷对切片中PAH蓄积的刺激作用抵消了急性肾衰竭大鼠切片中PAH蓄积的减少。
