Department of Psychiatry, Faculty of Medicine, Baskent University, Ankara, Turkey.
J Ren Nutr. 2010 Sep;20(5 Suppl):S51-5. doi: 10.1053/j.jrn.2010.06.001.
Sagliker syndrome (SS) is a novel syndrome that was described in 2004 in patients with chronic kidney disease (CKD). The aim of this study was to assess psychiatric evaluations and electroencephalography (EEG) findings of patients with CKD and SS to compare them with patients with CKD having characteristics similar to that of the study group, in terms of age and gender. The study group comprised 13 patients with CKD and SS. The control group included 13 patients with CKD. Psychiatric diseases were diagnosed using the Structure Clinical Interview. Beck Depression Inventory, Beck Anxiety Inventory, Social Comparison Scale, Hopelessness Scale, and Mini Mental State Examination (MMSE) were administered to the groups. Moreover, EEG recording for all the patients was performed. According to the results obtained from the Structure Clinical Interview, 69.2% of patients with CKD and SS were diagnosed with a mental disease, as compared with only 3 (23.1%) patients with CKD. There was a significant difference between the study and the control group (P < .001). As compared with the control group, patients with CKD and SS had significantly higher scores on the Beck Depression Inventory, the Beck Anxiety Inventory, and the Hopelessness Scale. However, patients with CKD and SS had significantly lower scores on the Social Comparison Scale. The MMSE scores were not significantly different between the 2 groups. When the 2 groups were evaluated separately, no significant differences were found between the EEG abnormalities and psychiatric diagnosis of both the groups. However, an evaluation of EEG abnormalities in all cases with CKD suggested a statistically significant difference between them. In the EEG recordings, electrical seizures activity was not enrolled in any of the cases. In the present study, psychiatric morbidity for patients with CKD and SS was worse than for patients with only CKD. These results indicate a need to develop an effective psychologic strategy for dealing with psychiatric disorders among patients with CKD and SS.
萨利克综合征（SS）是一种新型综合征，于 2004 年在慢性肾脏病（CKD）患者中描述。本研究旨在评估 CKD 患者的精神评估和脑电图（EEG）发现，并将其与具有与研究组相似特征的 CKD 患者进行比较，比较内容为年龄和性别。研究组包括 13 例 CKD 合并 SS 患者。对照组包括 13 例 CKD 患者。使用结构临床访谈对精神疾病进行诊断。对两组患者进行贝克抑郁量表、贝克焦虑量表、社会比较量表、绝望量表和简易精神状态检查（MMSE）。此外，对所有患者进行 EEG 记录。根据结构临床访谈的结果，69.2%的 CKD 合并 SS 患者被诊断为精神疾病，而 CKD 患者中仅有 3 例（23.1%）。研究组与对照组之间存在显著差异（P <.001）。与对照组相比，CKD 合并 SS 患者贝克抑郁量表、贝克焦虑量表和绝望量表的评分显著较高。然而，CKD 合并 SS 患者的社会比较量表评分显著较低。两组的 MMSE 评分无显著差异。当对两组分别进行评估时，两组的 EEG 异常与精神诊断之间没有发现显著差异。然而，对所有 CKD 患者的 EEG 异常评估表明，两组之间存在统计学上的显著差异。在 EEG 记录中，未记录到任何电发作活动。在本研究中，CKD 合并 SS 患者的精神发病率比单纯 CKD 患者更差。这些结果表明，需要为 CKD 合并 SS 患者制定有效的心理策略来应对精神障碍。
