Giray Semih, Sagliker Yahya, Yildiz Ismail, Halvaci Ilker, Paylar Nuray, Ocal Fatih, Balal Mustafa, Ozkaynak Piril Sagliker, Paydas Saime, Sagliker Cemal, Sagliker Hasan Sabit, Kiralp Necati, Adam Siddik Momin, Esenturk Mustafa, Gocmez Erdal, Taskapan Hulya, Yuksekgonul Musa, Emir Idris, Guler Turgay, Yakar Hasan, Sekin Oktay, Kayali Erkan, Caliskan Sihli, Eskiocak Ali Fuat, Ogruk Bulent, Guzelyurt Tamer, Kurt Cemal
Baskent University Adana Teaching and Research Hospital Neurology Department, Adana, Turkey.
J Ren Nutr. 2006 Jul;16(3):233-6. doi: 10.1053/j.jrn.2006.04.018.
Patients with chronic renal failure (CRF) often have signs and symptoms related to fluid and electrolyte disturbances, anemia, malnutrition, bone disease, and gastrointestinal problems. Vascular and neurologic impairment in particular remain an important source of morbidity and mortality in this vulnerable patient population. Sagliker syndrome is a novel syndrome that was recently described in 2004 in patients with CRF and severe and late secondary hyperparathyroidism who suffered from severe skull and facial bone changes, particularly from uglifying human face appearances and neuropsychiatric disorders. The goal of this study was to assess neuropsychiatric manifestations occurring in CRF patients with Sagliker syndrome. Four female and 8 male patients with CRF on regular dialysis at the hemodialysis units of the Internal Medicine Departments around southern Turkey participated in the study. All patients underwent a clinical neurologic examination performed by the same neurologist. Neuropsychiatric signs and symptoms were found in all cases. The results showed that the most frequent neurologic manifestations in CRF patients with Sagliker syndrome were headache, polyneuropathy, cranial neuropathy, fatigue, and psychiatric disorders.
慢性肾衰竭（CRF）患者常出现与体液和电解质紊乱、贫血、营养不良、骨病及胃肠道问题相关的体征和症状。特别是血管和神经功能损害，仍然是这类脆弱患者群体发病和死亡的重要原因。萨利克综合征是一种新型综合征，于2004年在患有严重晚期继发性甲状旁腺功能亢进的慢性肾衰竭患者中首次被描述，这些患者出现严重的颅骨和面部骨骼改变，尤其是面部容貌丑陋和神经精神障碍。本研究的目的是评估患有萨利克综合征的慢性肾衰竭患者出现的神经精神表现。土耳其南部各内科血液透析单位正在接受定期透析的4名女性和8名男性慢性肾衰竭患者参与了该研究。所有患者均由同一位神经科医生进行临床神经学检查。所有病例均发现神经精神体征和症状。结果显示，患有萨利克综合征的慢性肾衰竭患者最常见的神经学表现为头痛、多发性神经病、颅神经病、疲劳和精神障碍。
