AIMS

To investigate the association between airflow limitation and occupational exposure and to compare a fixed limit with an age adjusted limit for airflow limitation.

METHODS

3924 employees in 24 Norwegian smelters and related workplaces were investigated annually over 5 years (n=16, 570) using spirometry and a respiratory questionnaire on smoking habits and job category. Employees working full time on the production line were classified as line operators; subjects who never worked on the production line were regarded as non-exposed. A job exposure matrix (JEM) was available in most smelters. Airflow limitation was expressed as (i) forced expiratory volume in 1 s/forced vital capacity (FEV(1)/FVC ratio) <0.7 and (ii) FEV(1)/FVC ratio less than the lower limit of normal (LLN). Longitudinal analyses on the prevalence of airflow limitation were performed using a generalised linear mixed model.

RESULTS

The prevalence of airflow limitation was stable during follow-up. The OR of airflow limitation during follow-up was 1.24 (95% CI 1.03 to 1.50) in line operators compared with unexposed subjects for FEV(1)/FVC ratio <0.7 and 1.44 (1.14 to 1.81) for FEV(1)/FVC ratio <LLN. A dose-response relationship was also found between prevalence of airflow limitation and dust exposure. The annual decline in FEV(1) was -77.5 (SD 99.9) ml/year in subjects with FEV(1)/FVC ratio <0.7 and -83.8 (114.2) ml/year in subjects with FEV(1)/FVC ratio <LLN.

CONCLUSION

Prevalence of airflow limitation was higher in exposed than non-exposed employees. Both the FEV(1)/FVC ratio <0.7 and FEV(1)/FVC ratio <LLN identify subjects with accelerated annual decline in FEV(1).