Department of Medicine, Faculty Division Akershus University Hospital, University of Oslo, Lørenskog, Norway.
Am J Ind Med. 2011 Sep;54(9):707-13. doi: 10.1002/ajim.20946. Epub 2011 Feb 28.
We have investigated the association between the incidence of airflow limitation and occupational exposure. The employees (n = 3,924) were investigated annually during five years (n = 16,570) using spirometry. Exposure was classified using job category and a job exposure matrix. Airflow limitation was expressed using two indices: (i) as forced expiratory volume in one second/force vital capacity (FEV(1) /FVC) <0.7 and (ii) lower limit of normal (LLN). The incidence of airflow limitation was 21.2/1000 years(-1) and 15.1/1000 years(-1) using the fixed limit (0.7) and the LLN criterion, respectively. We found a dose-response relationship between the incidence of airflow limitation and tobacco consumption and with job-category in non-smokers. The associations between airflow limitation and covariates were independent of how airflow limitation was defined. The incidence of airflow limitation defined as FEV(l) /FVC <0.7 yielded higher incidence rates of airflow limitation than LLN. We found a significant association between the incidence of airflow limitation and occupational exposure in non-smokers.
我们研究了气流受限的发生率与职业暴露之间的关联。在五年期间（n=16570），每年对员工（n=3924）进行了肺量测定检查。使用职业类别和职业暴露矩阵对暴露进行分类。气流受限使用两个指标表示：（i）第 1 秒用力呼气量/用力肺活量（FEV(1) /FVC）<0.7 和（ii）正常下限（LLN）。使用固定限值（0.7）和 LLN 标准，气流受限的发生率分别为 21.2/1000 年（-1）和 15.1/1000 年（-1）。我们发现气流受限的发生率与吸烟量和非吸烟者的职业类别之间存在剂量反应关系。气流受限与协变量之间的关联与气流受限的定义无关。FEV(l) /FVC <0.7 定义的气流受限发生率高于 LLN。我们发现非吸烟者气流受限的发生率与职业暴露之间存在显著关联。
