Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden.
Dement Geriatr Cogn Disord. 2010;30(3):198-204. doi: 10.1159/000319535. Epub 2010 Aug 26.
Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cognitive impairment.
We have investigated the relation between plasma tHcy, its determinants and cognition, measured as MMSE, in 448 consecutively enrolled patients with dementia or other psychogeriatric diseases.
Multiple regression analyses showed that plasma tHcy was related to cognitive function in all patients as well as in demented and non-demented patients. The apparent close relationship between plasma tHcy and cognition was mainly dependent on its determinant age, whereas the other determinants of plasma tHcy exhibited a limited influence on the relation between plasma tHcy and cognition. Plasma tHcy has its own, albeit modest, relationship to cognitive function (predictive value about 5%).
Plasma tHcy itself seems to play a minor role in cognitive impairment in patients with dementia or other psychogeriatric diseases. When investigating the relation between plasma tHcy and cognition, it is important to consider the distribution of the main determinants of plasma tHcy and to correct plasma tHcy for these variables.
精神疾病老年患者的全血浆同型半胱氨酸（tHcy）浓度升高，且伴有血管疾病的患者的血浆 tHcy 浓度高于无血管疾病的患者。越来越多的证据表明，血管危险因素在认知障碍的发展中起作用。
我们研究了 448 例连续入组的痴呆或其他精神老年疾病患者的血浆 tHcy、其决定因素与认知功能（用 MMSE 测量）之间的关系。
多元回归分析表明，血浆 tHcy 与所有患者以及痴呆和非痴呆患者的认知功能有关。血浆 tHcy 与认知之间的明显密切关系主要取决于其决定因素年龄，而血浆 tHcy 的其他决定因素对血浆 tHcy 与认知之间的关系影响有限。血浆 tHcy 与其自身的认知功能（预测值约为 5%）有一定的关系。
血浆 tHcy 本身似乎在痴呆或其他精神老年疾病患者的认知障碍中作用较小。在研究血浆 tHcy 与认知之间的关系时，考虑血浆 tHcy 的主要决定因素的分布并对这些变量进行血浆 tHcy 校正很重要。
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