伊朗东北部老年人的同型半胱氨酸、钴胺素和叶酸状况及其与神经认知和心理标志物的关系。

Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive and Psychological Markers in Elderly in Northeasten of Iran.

机构信息

Paramedical School, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran J Basic Med Sci. 2013 Jun;16(6):772-80.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3758032/

Abstract

OBJECTIVE(S): Incidence of neurocognitive and psychological disorders may be related to serum homocystein (Hcy), cobalamin (vitamin B12) and folate levels in old people. The aim of this study was to assess the relation between Hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly.

MATERIALS AND METHODS

In this cross-sectional study, 280 subjects with ≥ 65 years old ,were evaluated. The subjects were selected from 12 regions of Mashhad, Iran, over March to October 2009. After blood sampling, data were collected by questionnaire, face to face interview and performing neurocognitive and psychological tests. The sera of 250 persons were analyzed for cobalamin and folate by RIA method. Amongst the aforementioned samples, 78 cases with cobalamin <300 pg/ml and folate <6.5 ng/ml were analyzed for Hcy by ELISA method.

RESULTS

Amongst the people, 126 (45%) were male and 154 (55%) were female. The prevalence of hyperhomocysteinemia (HHcy) was 59.5% and 37.1% in male and female respectively (P -value =0.049). Hcy inversely correlated to cobalamin (r=-0.282, P=0.014) and to folate (r=-0.203, P=0.014). Hcy, cobalamin and folate correlations to neurocognitive and psychological impairments were not statically significant.

CONCLUSION

Hyper Hcy or low cobalamin and folate in the elderly, are prevalent but their relationships with neurocognitive and psychological impairments is controversial. If these relationships had been confirmed, performing a single serum Hcy or cobalamin test would have been enough enough to diagnose and prevent neurocognitive impairments and inversely, neurocognitive-psychological sign and symptoms could have meant probable tissue vitamin deficiencies. However methods of assessing neurocognitive and psychological markers with validity and reliability of clinical and laboratory tests for finding aforementioned relationships should be revised.

摘要

目的

神经认知和心理障碍的发病率可能与老年人的血清同型半胱氨酸（Hcy）、钴胺素（维生素 B12）和叶酸水平有关。本研究旨在评估老年人中 Hcy、钴胺素、叶酸与神经认知和/或心理障碍之间的关系。

材料和方法

在这项横断面研究中，评估了 280 名年龄≥65 岁的受试者。这些受试者是 2009 年 3 月至 10 月从伊朗马什哈德的 12 个地区中选择的。采血后，通过问卷调查、面对面访谈和进行神经认知和心理测试收集数据。250 人的血清采用 RIA 法分析钴胺素和叶酸。在上述样本中，78 例钴胺素<300pg/ml 和叶酸<6.5ng/ml 的人采用 ELISA 法分析 Hcy。

结果

在这些人中，126 人（45%）为男性，154 人（55%）为女性。高同型半胱氨酸血症（HHcy）的患病率在男性和女性中分别为 59.5%和 37.1%（P 值=0.049）。Hcy 与钴胺素呈负相关（r=-0.282，P=0.014），与叶酸呈负相关（r=-0.203，P=0.014）。Hcy、钴胺素和叶酸与神经认知和心理障碍的相关性无统计学意义。

结论

老年人中高 Hcy 或低钴胺素和叶酸很常见，但它们与神经认知和心理障碍的关系存在争议。如果这些关系得到证实，那么进行单次血清 Hcy 或钴胺素检测就足以诊断和预防神经认知障碍，反之，神经认知-心理症状可能意味着可能存在组织维生素缺乏。然而，应该修订评估神经认知和心理标志物的方法，以提高临床和实验室检测的有效性和可靠性，以寻找上述关系。