XRCC1基因多态性对电离辐射诱导的DNA损伤及修复的影响
Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair.
作者信息
Sterpone Silvia, Cozzi Renata
机构信息
Department of Biology, University of "Roma TRE", Viale Guglielmo Marconi 446, 00146 Rome, Italy.
出版信息
J Nucleic Acids. 2010 Jul 25;2010:780369. doi: 10.4061/2010/780369.
Abstract
It is well known that ionizing radiation (IR) can damage DNA through a direct action, producing single- and double-strand breaks on DNA double helix, as well as an indirect effect by generating oxygen reactive species in the cells. Mammals have evolved several and distinct DNA repair pathways in order to maintain genomic stability and avoid tumour cell transformation. This review reports important data showing a huge interindividual variability on sensitivity to IR and in susceptibility to developing cancer; this variability is principally represented by genetic polymorphisms, that is, DNA repair gene polymorphisms. In particular we have focussed on single nucleotide polymorphisms (SNPs) of XRCC1, a gene that encodes for a scaffold protein involved basically in Base Excision Repair (BER). In this paper we have reported and presented recent studies that show an influence of XRCC1 variants on DNA repair capacity and susceptibility to breast cancer.
摘要
众所周知，电离辐射（IR）可通过直接作用损伤DNA，在DNA双螺旋上产生单链和双链断裂，还可通过在细胞中产生氧活性物质产生间接效应。哺乳动物进化出了多种不同的DNA修复途径，以维持基因组稳定性并避免肿瘤细胞转化。本综述报告了重要数据，显示个体对IR的敏感性以及患癌易感性存在巨大差异；这种差异主要由基因多态性，即DNA修复基因多态性所体现。特别是，我们聚焦于XRCC1的单核苷酸多态性（SNP），该基因编码一种主要参与碱基切除修复（BER）的支架蛋白。在本文中，我们报告并展示了近期研究，这些研究表明XRCC1变体对DNA修复能力和乳腺癌易感性有影响。
相似文献
1
Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair.
J Nucleic Acids. 2010 Jul 25;2010:780369. doi: 10.4061/2010/780369.
2
Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese population.
Asian Pac J Cancer Prev. 2014;15(3):1133-40. doi: 10.7314/apjcp.2014.15.3.1133.
3
Genetic polymorphisms in XRCC1, OGG1, and XRCC3 DNA repair genes and DNA damage in radiotherapy workers.
Environ Sci Pollut Res Int. 2020 Dec;27(35):43786-43799. doi: 10.1007/s11356-020-10270-9. Epub 2020 Aug 1.
4
Association of DNA base-excision repair XRCC1, OGG1 and APE1 gene polymorphisms with nasopharyngeal carcinoma susceptibility in a Chinese population.
Asian Pac J Cancer Prev. 2013;14(9):5145-51. doi: 10.7314/apjcp.2013.14.9.5145.
5
XRCC1 deficiency increased the DNA damage induced by γ-ray in HepG2 cell: Involvement of DSB repair and cell cycle arrest.
Environ Toxicol Pharmacol. 2013 Sep;36(2):311-319. doi: 10.1016/j.etap.2013.04.009. Epub 2013 May 2.
6
XRCC1 and base excision repair balance in response to nitric oxide.
DNA Repair (Amst). 2011 Dec 10;10(12):1282-93. doi: 10.1016/j.dnarep.2011.10.008. Epub 2011 Oct 29.
7
Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD.
Mol Vis. 2010 Apr 20;16:698-704.
8
Genetic factors in individual radiation sensitivity.
DNA Repair (Amst). 2014 Apr;16:54-65. doi: 10.1016/j.dnarep.2014.02.001. Epub 2014 Mar 4.
9
Association of -77T>C and Arg194trp polymorphisms of XRCC1 with risk of coronary artery diseases in Iranian population.
Iran J Basic Med Sci. 2016 Feb;19(2):194-200.
10
PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.
DNA Repair (Amst). 2008 Oct 1;7(10):1746-56. doi: 10.1016/j.dnarep.2008.06.017. Epub 2008 Aug 22.
引用本文的文献
1
Interaction of breast cancer-relevant DNA repair genes and air pollution in relation to breast cancer risk in UK biobank.
Am J Cancer Res. 2024 Dec 15;14(12):5935-5951. doi: 10.62347/WNIY6250. eCollection 2024.
2
CRISPR/Cas9 system: a novel approach to overcome chemotherapy and radiotherapy resistance in cancer.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):3373-3408. doi: 10.1007/s00210-024-03480-2. Epub 2024 Nov 19.
3
Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts.
PLoS Genet. 2022 Dec 7;18(12):e1010080. doi: 10.1371/journal.pgen.1010080. eCollection 2022 Dec.
4
Understanding Role of DNA Repair and Cytochrome p-450 Gene Polymorphisms in Cervical Cancer Patient Treated With Concomitant Chemoradiation.
Br J Biomed Sci. 2022 Feb 24;79:10120. doi: 10.3389/bjbs.2021.10120. eCollection 2022.
5
Mechanism Study on Radiosensitization Effect of Curcumin in Bladder Cancer Cells Regulated by Filamin A.
Dose Response. 2022 Jun 2;20(2):15593258221100997. doi: 10.1177/15593258221100997. eCollection 2022 Apr-Jun.
6
Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment.
MedComm (2020). 2021 Jun 10;2(3):315-340. doi: 10.1002/mco2.55. eCollection 2021 Sep.
7
Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation.
Genes Environ. 2021 Mar 8;43(1):9. doi: 10.1186/s41021-021-00176-4.
8
Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma.
Invest New Drugs. 2019 Aug;37(4):646-657. doi: 10.1007/s10637-018-0667-9. Epub 2018 Oct 17.
9
SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand.
Oncotarget. 2018 May 18;9(38):25355-25382. doi: 10.18632/oncotarget.25256.
10
Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays.
Radiat Res. 2018 Jul;190(1):53-62. doi: 10.1667/RR14990.1. Epub 2018 May 10.
本文引用的文献
1
Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women.
J Cancer Res Clin Oncol. 2010 Apr;136(4):631-6. doi: 10.1007/s00432-010-0791-1. Epub 2010 Feb 6.
2
DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients.
Mutat Res. 2010 Feb 3;684(1-2):43-8. doi: 10.1016/j.mrfmmm.2009.11.009. Epub 2009 Dec 3.
3
Effects of cigarette smoking, XRCC1 genetic polymorphisms, and age on basal DNA damage in human blood mononuclear cells.
Mutat Res. 2009 Sep-Oct;679(1-2):59-64. doi: 10.1016/j.mrgentox.2009.07.005. Epub 2009 Jul 21.
4
XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis.
Mutagenesis. 2009 Jul;24(4):331-9. doi: 10.1093/mutage/gep013. Epub 2009 May 22.
5
DNA repair in mammalian cells: Base excision repair: the long and short of it.
Cell Mol Life Sci. 2009 Mar;66(6):981-93. doi: 10.1007/s00018-009-8736-z.
6
DNA repair in mammalian cells : Nucleotide excision repair: variations on versatility.
Cell Mol Life Sci. 2009 Mar;66(6):994-1009. doi: 10.1007/s00018-009-8737-y.
7
DNA Repair in mammalian cells: Mismatched repair: variations on a theme.
Cell Mol Life Sci. 2009 Mar;66(6):1021-38. doi: 10.1007/s00018-009-8739-9.
8
Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures.
Breast Cancer Res Treat. 2009 May;115(1):137-44. doi: 10.1007/s10549-008-0051-0. Epub 2008 May 15.
9
Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein.
Protein J. 2007 Dec;26(8):541-6. doi: 10.1007/s10930-007-9095-y.
10
Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.
J Natl Cancer Inst. 2006 Oct 4;98(19):1382-96. doi: 10.1093/jnci/djj374.
Zotero 插件