Speech Pathology and Audiology, Marquette University, Milwaukee, WI 53201-1881, USA.
Curr Neurol Neurosci Rep. 2010 Nov;10(6):491-8. doi: 10.1007/s11910-010-0146-y.
Emerging neurologic evidence has suggested that developmental and acquired stuttering may have a cerebral base. Investigations have revealed compensatory activation in the right cortical motor areas and deactivation in the left perisylvian region in subjects with persistent developmental stuttering. The evidence has also implicated limbic (cingulate)-basal ganglia regions. Increased speech fluency with treatment in such subjects eliminated compensatory brain activity and shifted activation back to the left hemisphere. We assess the neurology of stuttering and then present our own observations of deep brain stimulation of the thalamus with some ameliorating effect on the encompassing syndrome with speech dysfluency.
新兴的神经学证据表明，发展性和获得性口吃可能有大脑基础。研究表明，在持续性发展性口吃患者中，大脑右侧皮质运动区出现代偿性激活，左侧周围大脑区域出现失活。证据还涉及边缘（扣带回）-基底节区域。在这些患者中，治疗后言语流畅度增加，代偿性大脑活动消除，激活恢复到左半球。我们评估口吃的神经学，然后介绍我们自己对丘脑深部电刺激的观察结果，发现对伴有言语不流畅的综合症状有一定的改善效果。
