Catley Matthew C
UCB Celltech, 208 Bath Road, Slough, UK.
IDrugs. 2010 Sep;13(9):601-4.
The International Quality & Productivity Center's (IQPC) Second Asthma & COPD conference, held in Philadelphia, included topics covering new therapeutic developments in the field of asthma and COPD. This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa, CCR3 inhibitors, histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies. Investigational drugs discussed include mepolizumab (GlaxoSmithKline plc), benralizumab (BioWa Inc/Kyowa Hakko Kirin Co Ltd/MedImmune LLC), AMG-317 (Amgen Inc/Takeda Bio Development Center Ltd), TPI-ASM-8 (Pharmaxis Ltd) and AIR-645 (Altair Therapeutics Inc).
国际质量与生产力中心(IQPC)在费城举办的第二届哮喘与慢性阻塞性肺疾病会议涵盖了哮喘和慢性阻塞性肺疾病领域新治疗进展的相关主题。本会议报告重点介绍了关于哮喘单克隆抗体治疗的部分演讲内容,包括针对白细胞介素-5、白细胞介素-13、白细胞介素-9和肿瘤坏死因子α的治疗、CCR3抑制剂、组胺H4受体抑制、慢性阻塞性肺疾病新型小鼠模型以及吸入性反义哮喘疗法。所讨论的研究药物包括美泊利单抗(葛兰素史克公司)、贝那利珠单抗(保和制药株式会社/协和麒麟株式会社/MedImmune有限责任公司)、AMG - 317(安进公司/武田生物开发中心有限公司)、TPI - ASM - 8(法玛西斯有限公司)和AIR - 645(阿尔泰治疗公司)。