Heinrich Norbert, Born M, Hoebert E, Verrel F, Simon A, Bode U, Fleischhack G
Dept. of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany.
Vasa. 2010 Aug;39(3):271-3. doi: 10.1024/0301-1526/a000042.
After cisplatin / 5-fluorouracil chemotherapy for nasopharyngeal carcinoma, an 18-year female patient developed aortobifemoral embolism. Besides chemotherapy, additional risk factors for arterial thromboembolic events were smoking, contraceptive medication and adjuvant antiemetic treatment with dexamethasone. Thrombophilia screening was negative. Thromboembolic complications during or after cisplatin have been reported in a frequency of 17.6 % in lung cancer patients, and in 8.4 % of patients with germ cell tumors. The incidence of arterial thromboembolic events was 9.3 % and 1.7 %, respectively. The pathogenesis of cisplatin induced thromboembolism is thought to be caused by endothelial damage leading to endothelial cell dysfunction, increased von Willebrand factor plasma levels, and hypomagnesaemia.
一名18岁女性鼻咽癌患者在接受顺铂/5-氟尿嘧啶化疗后发生了主-双股动脉栓塞。除化疗外，动脉血栓栓塞事件的其他危险因素包括吸烟、避孕药和地塞米松辅助止吐治疗。血栓形成倾向筛查为阴性。据报道，肺癌患者顺铂治疗期间或之后血栓栓塞并发症的发生率为17.6%，生殖细胞肿瘤患者为8.4%。动脉血栓栓塞事件的发生率分别为9.3%和1.7%。顺铂诱导血栓栓塞的发病机制被认为是由内皮损伤导致内皮细胞功能障碍、血管性血友病因子血浆水平升高和低镁血症引起的。
