,of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
East Mediterr Health J. 2010 May;16(5):563-9.
This study evaluated the role of periodontal pathogens in 50 hospitalized patients with hospital acquired pneumonia compared with 30 healthy controls. Specimens of oropharyngeal aspirate, dental plaque bronchoalveolar lavage and blood cultured 1 or more pathogens in around 80% of patients, predominatel Staphylococcus aureus, followed by coagulase-negative staphylococci, Streptococcus pneumoniae and Klebsiell pneumoniae. Antibiotic sensitivity patterns showed concordance of bacterial cultures from dental plaque an oropharyngeal cavity in 13 patients. C-reactive protein (CRP) levels were significantly higher in patients than ii controls and there was a significant correlation between serum and salivary CR1' levels. Dental plaque bioflln may promote oral and oronpharyngeal colonization of respiratory pathogens in hospitalized subiects.
本研究评估了牙周病原体在 50 名医院获得性肺炎住院患者中的作用，并与 30 名健康对照进行了比较。口咽抽吸物、牙菌斑、支气管肺泡灌洗液和血液标本培养出 1 种或多种病原体的患者约占 80%，主要为金黄色葡萄球菌，其次为凝固酶阴性葡萄球菌、肺炎链球菌和肺炎克雷伯菌。抗生素敏感性模式显示，13 例患者的牙菌斑和口咽腔细菌培养结果一致。与对照组相比，患者的 C 反应蛋白（CRP）水平显著升高，血清和唾液 CRP 水平之间存在显著相关性。牙菌斑生物膜可能促进住院患者口腔和口咽部呼吸道病原体的定植。
