Wang S M, Nishigori C K, Zhang J M, Takebe H
Department of Experimental Radiology, Kyoto University, Japan.
Mutat Res. 1990 Sep-Nov;237(5-6):253-7. doi: 10.1016/0921-8734(90)90007-e.
A Chinese boy was identified to be suffering from progeria (Hutchinson-Gilford syndrome), the first case of the disease ever reported in China. Cells originating from the patient had a reduced amount of unscheduled DNA synthesis after irradiation with ultraviolet light (UV). The fractions of the progeria cells surviving against UV irradiation measured by colony-forming ability, and the host-cell reactivation capacity of the progeria cells, measured by the plaque formation of UV-irradiated herpes simplex virus were lower than those measured in normal cells. The progeria cells appear to have a reduced capacity to repair UV excision damage.
一名中国男孩被确诊患有早老症（哈钦森 - 吉尔福德综合征），这是中国首例该疾病报告。患者来源的细胞在紫外线（UV）照射后，其非预定DNA合成量减少。通过集落形成能力测定的早老症细胞在紫外线照射下的存活分数，以及通过紫外线照射的单纯疱疹病毒斑块形成测定的早老症细胞的宿主细胞再激活能力，均低于正常细胞。早老症细胞似乎修复紫外线切除损伤的能力降低。
