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壳聚糖及其N-磺基琥珀酰衍生物的伤口愈合潜力

[Wound healing potential of chitosan and its N-sulfosuccinoyl derivatives].

作者信息

Alekseeva T P, Rakhmetova A A, Bogoslovskaia O A, Ol'khovskaia I P, Levov A N, Il'ina A V, Varlamov V P, Baĭtukalov T A, Glushchenko N N

出版信息

Izv Akad Nauk Ser Biol. 2010 Jul-Aug(4):403-10.

Abstract

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.

摘要

利用实验性全层皮肤伤口模型,对壳聚糖及其在MC - 100凝胶中合成衍生物的伤口愈合特性进行了比较研究。结果表明,以0.05%的浓度添加到凝胶中的N - 磺基琥珀酰壳聚糖衍生物与其他壳聚糖衍生物相比,具有更高的伤口愈合活性,与对照组相比,伤口的半愈合期缩短了2至3倍。

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