J Biomed Opt. 2010 Jul-Aug;15(4):040509. doi: 10.1117/1.3475956.
According to classical theory, visual acuity (VA) can be modeled using the intersection of the eye's modulation transfer function with a retinal threshold function. To date, there have been limited attempts to validate this methodology by comparing theory with actual measured data. We use the methodology to predict the visual acuity in the presence of defocus of a population of cataract patients implanted with diffractive multifocal intraocular lenses. For the prediction, we used a set of physiological eye models that include chromatic and higher order aberrations. We found that the simulations correlated strongly to the clinical outcomes (R(2)=0.93). While the simulated VA of the eye models was systematically 0.05 logMAR units lower (better acuity) than the clinical results, this difference was independent of defocus (p=0.98). These results show that when the simple and straightforward classical theory is applied using physiological eye models, accurate predictions of the VA, and through-focus VA of a population can be made. This method may be suited for predicting visual performance of new cataract and refractive treatments.
根据经典理论，视力（VA）可以通过眼睛的调制传递函数与视网膜阈值函数的交点来建模。迄今为止，通过将理论与实际测量数据进行比较来验证该方法的尝试有限。我们使用该方法来预测患有衍射多焦点人工晶状体的白内障患者的离焦状态下的视力。为了进行预测，我们使用了一组包含色觉和高阶像差的生理眼模型。我们发现模拟结果与临床结果高度相关（R(2)=0.93）。虽然眼模型模拟的 VA 比临床结果低 0.05 个 logMAR 单位（更好的视力），但这种差异与离焦无关（p=0.98）。这些结果表明，当使用生理眼模型应用简单明了的经典理论时，可以对人群的 VA 和焦点内 VA 进行准确预测。该方法可能适用于预测新的白内障和屈光治疗的视觉性能。
