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富含亮氨酸重复蛋白 PRAME：白血病的表达、潜在功能和临床意义。

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.

机构信息

Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, UK.

出版信息

Mol Cancer. 2010 Aug 27;9:226. doi: 10.1186/1476-4598-9-226.

DOI:10.1186/1476-4598-9-226
PMID:20799951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2936344/
Abstract

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.

摘要

PRAME/MAPE/OIP4 是一种生殖组织特异性基因，在血液恶性肿瘤和实体肿瘤中也高水平表达。PRAME 在正常和肿瘤细胞中的生理功能未知，尽管有人提出它在视黄酸信号转导的调节中起作用。序列同源性和结构预测表明 PRAME 与富含亮氨酸重复（LRR）家族的蛋白质有关，这些蛋白质具有多种功能。本文综述了 PRAME 的结构/功能及其在白血病中的相关性的最新知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/cd6451180367/1476-4598-9-226-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/7cac79d31d7c/1476-4598-9-226-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/b9e70b298046/1476-4598-9-226-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/cd6451180367/1476-4598-9-226-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/7cac79d31d7c/1476-4598-9-226-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/b9e70b298046/1476-4598-9-226-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/2936344/cd6451180367/1476-4598-9-226-3.jpg

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Evolution and functional divergence of NLRP genes in mammalian reproductive systems.NLRP基因在哺乳动物生殖系统中的进化与功能分化
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The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.
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Targeting PRAME for acute myeloid leukemia therapy.针对急性髓系白血病的 PRAME 靶向治疗。
Front Immunol. 2024 Mar 26;15:1378277. doi: 10.3389/fimmu.2024.1378277. eCollection 2024.
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Exp Hematol Oncol. 2024 Apr 3;13(1):37. doi: 10.1186/s40164-024-00504-8.
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