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[药物干扰以及麻醉在这种干扰中的作用]

[Drug interference and the role of anesthesia in such interference].

作者信息

Lareng L, Bertrand J C

出版信息

Ann Anesthesiol Fr. 1975;16 Spec No 1:25-58.

PMID:2080
Abstract

This report considers interference between medications for, on the one hand, drugs given during pregnancy, and, on the other hand, drugs given to the pregnant women and anaesthetic agents. Consideration is given to progestational agents, oxytocics, beta-mimetics, corticosteroids, insulin, hypotensive agents, diuretics and psychiatric drugs. For each case of interference, an attempt is made to provide practical data, with particular respect to those combinations frequently prescribed by obstetricians, e.g. the combination of the beta-mimetics and corticosteroids with the aim of preventing impending premature onset of labour and to ensure foetal pulmonary maturation; the combination of insulin and corticosteroids given to diabetics with the aim of preventing hyaline membrane disease; the combination of corticosteroids with anti-histamines in the treatment of rhesus disease; the association of oxytocics with large quantities of intravenous fluid in the case of post-partum haemorrhage and hypontensive medication combinations and the problems which may result with emergency anaesthesis.

摘要

本报告考虑了一方面孕期用药之间的相互干扰,另一方面是给予孕妇的药物与麻醉剂之间的相互干扰。其中涉及孕激素、催产素、β-拟交感神经药、皮质类固醇、胰岛素、降压药、利尿剂和精神药物。对于每一种干扰情况,都试图提供实际数据,尤其关注产科医生经常开具的药物组合,例如,β-拟交感神经药与皮质类固醇联合使用以预防即将发生的早产并确保胎儿肺成熟;糖尿病患者使用胰岛素与皮质类固醇联合以预防透明膜病;皮质类固醇与抗组胺药联合用于治疗恒河猴血型不合疾病;产后出血时催产素与大量静脉输液联合使用以及降压药物组合以及紧急麻醉可能引发的问题。

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