Andréjak M, Slama M, Hary L
Service de Pharmacologie Clinique, CHU Sud, Amiens, France.
Therapie. 1998 May-Jun;53(3):291-300.
First-line antihypertensive monotherapy is effective in normalizing blood pressure in approximatively 50 per cent of patients. Normalization in the remaining patients may require a combination of two or more drugs. This review considers the rationale and the evaluation of combinations with drugs interacting with the renin-angiotensin system (i.e. angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists) with other drugs. The combinations may be justified when giving an additive or synergistic action and when reducing clinical or metabolic side-effects. Recent developments concern the potential benefit of combining ACEI and angiotensin receptor antagonists.
一线降压单药治疗对约50%的患者有效，可使血压恢复正常。其余患者可能需要联合使用两种或更多药物才能使血压恢复正常。本综述探讨了将肾素 - 血管紧张素系统相互作用药物（即血管紧张素转换酶抑制剂（ACEI）和血管紧张素受体拮抗剂）与其他药物联合使用的基本原理及评估。当联合用药具有相加或协同作用且能减少临床或代谢副作用时，联合用药可能是合理的。最近的进展涉及联合使用ACEI和血管紧张素受体拮抗剂的潜在益处。
